I had an issue where a client's antivirus program (Symantec EndPoint) was outdated and there was no way to update the virus definitions from the program. The LiveUpdate button was disabled when the program was installed.
HKEY_LOCAL_MACHINE\SOFTWARE\Symantec\Symantec Endpoint Protection\LiveUpdate\AllowManualLiveUpdate
The value must be 1 to enable the LiveUpdate button on Clients side.